On July 29, 2019, the Blue Jays selected Bichette’s contract and promoted him to the major leagues. On that day, he recorded his first major league hit, a single against Brad Keller of the Kansas City Royals, on just the second major league pitch he saw. On July 31, Bichette recorded three hits against the Royals, the second of which was his first MLB home run. On August 6, Bichette became the first ever MLB player to hit 10 extra base hits in his first nine major league games with a double against the Tampa Bay Rays. After hitting another double on August 7, Bichette joined Yadier Molina and Derrek Lee as the only players in the live-ball era to record a double in eight-straight games, and broke the Blue Jays franchise record set by Carlos Delgado in 2000. Playing in Toronto for the first time the following day, Bichette extended his doubles streak to nine games, setting a new MLB record. He also set a new MLB record in extra base hits in the first 11 games of his career with 13. He is the first rookie with 9 straight games with extra base hits since Ted Williams in 1939. Bichette set franchise records with 20 hits and an 11-game hit streak with 1.316 OPS during the 11-game span. He finished the season hitting .311 with 11 home runs in 46 games.
Overall with the 2020 Blue Jays, Bichette batted .301 with five home runs and 23 RBIs in 29 games.
On July 4, 2021, Bichette was named an All-Star for the first time in his career. At the time of his nomination, Bichette had a slash line of .290/.340/.529 and had 15 home runs and 54 RBI.
